學歷
學校 系所 學位
國防醫學院 生物化學研究所 碩士
台北醫學院 保健營養系 學士
國防醫學院 生命科學研究所 博士
經歷
期間 單位 部門 職稱
2022 / 8 - 輔仁大學 呼吸治療學系 教授
2013 / 8 - 2022 / 7 輔仁大學 呼吸治療學系 副教授
2010 / 2 - 2013 / 7 輔仁大學 呼吸治療學系 助理教授
2000 / 1 - 2001 / 7 美商默沙東藥廠 醫藥部門 臨床研究專員
專長
分子生物學
急性肺損傷
藥物開發
肺癌機轉
營養生理生化
學術著作
期刊論文
期間 內容
2021-10 Jung, F.,Liu, JS,Yang, SH,Tseng, HY,Chou, SS P.,Lin, JC,Jow, GM,'FJU-C28 inhibits the endotoxin-induced pro-inflammatory cytokines expression via suppressing JNK, p38 MAPK and NF-κB signaling pathways',Pharmacol Res Perspect.,vol9.e00876,2021-10
2021-06 ,'Closed Endotracheal Suctioning Impact on Ventilator-Related Parameters in Obstructive and Restrictive Respiratory Systems: A Bench Study',Appl. Sci.,vol11.5266,2021-06
2021-04 ,'Optimizing effects on airway pressure and minute volume during closed endotracheal suctioning: a simulated lung model',Simulation,vol97.439-449,2021-04
2019-03 林昭成,曾惠芸,龍芳,楊式興,'Elevation of IL-6 and IL-33 Levels in Serum Associated with Lung Fibrosis and Skeletal Muscle Wasting in a Bleomycin-Induced Lung Injury Mouse Model',Mediators of Inflammation,volVolume 2019.12,2019-03
2017-08 林昭成,'Antofine suppresses endotoxin-induced inflammation and metabolic disorder via AMP-activated protein kinase',Pharmacol Res Perspect,vol5.14,2017-08
2016-10 林昭成,'Effects of hydrocortisone on activation of inflammation via interleukin-33 in ventilator-induced lung injury',Chin J Physiol.,vol59.284-292,2016-10
2015-11 林昭成,'A promising hypothesis of c-KIT methylation/ expression paradox in c-KIT (+) squamous cell carcinoma of uterine cervix - CTCF transcriptional repressor regulates c-KIT proto-oncogene expression.',Diagnostic Pathology,vol10.1-3,2015-11
2015-03 林昭成,'Membrane Translocation of IL-33 Receptor in Ventilator Induced Lung Injury',PLoS One,vol10.e0121391,2015-03
2015-01 林昭成,'Unusual c-KIT+ squamous cell carcinoma of the uterine cervix showing paradoxical hypermethylation of the c-KIT proto-oncogene',Eur J Obstet Gynecol Reprod Biol,vol184.130-131,2015-01
2014-04 林昭成,'HER2 amplification and overexpression are significantly correlated in mucinous epithelial ovarian cancer',Human Pathology,vol45.810-816,2014-04
2014-01 林昭成,'The antitumor agent PBT-1 directly targets HSP90 and hnRNP A2/B1 and inhibits lung adenocarcinoma growth and metastasis',J Med Chem,vol57.677,2014-01
2013-12 Chao WR, Lin JC,Huang YC,Chen CK,Han CP,'Anticytokeratin CAM 5.2 Does not Correspond to Antibodies CK 8/18',Head Neck Pathol,vol4.398,2013-12
2013-12 Liu JS,Jung F,Yang SH,Chou S-S P,Huang JL,Lu CL,Huang GL,Yang PC,Lin JC,Jow GM,'FJU-C4, a New 2-Pyridone Compound, Attenuates Lipopolysaccharide-Induced Systemic Inflammation via p38MAPK and NF-κB in Mice',Plos one,vol8.e82877,2013-12
2013-05 Ching-Wen Lin,Yih-Leong Chang,Yu-Chiuan Chang,Jau-Chen Lin,Tse-Ming Hong,Pan-Chyr Yang,'MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1',NATURE COMMUNICATIONS.1877,2013-05
2013-03 Huang, Y. F,Liao, C. K.,Lin, J. C.,Jow, G. M.,Wang, H. S.,Wu, J. C.,'Antofine-induced connexin43 gap junction disassembly in rat astrocytes involves protein kinase Cβ',Neurotoxicology,vol35.169-179,2013-03
2013-01 楊式興,朱秋蓉,陸嘉真,簡辰霖,林昭成,卓貴美,龍芳,'某獨立型居家護理所導入長期呼吸器依賴患者整合性照護計畫之服務現況分析',呼吸治療,vol12.1-14,2013-01
2012-06 Jau-Chen Lin,Yi-Ying Wu,Jing-Yi Wu,Tzu-Chieh Lin,Chen-Tu Wu,Yih-Leong Chang,Yuh-Shan Jou,Tse-Ming Hong,Pan-Chyr Yang,'TROP2 is Epigenetically Inactivated and Modulates IGF-1R Signaling in Lung Adenocarcinoma',EMBO molecular medicine,vol4.472–485,2012-06
2011-08 Wu YY,Peck K,Chang YL,Pan SH,Cheng YF,Lin JC,Yang RB,Hong TM,Yang PC,'SCUBE3 is an endogenous TGF-β receptor ligand and regulates the epithelial-mesenchymal transition in lung cancer',Oncogene,vol30.3682-3693,2011-08
2011-07 Yang, X ,Shi, Q. ,Yang, S. C. ,Chen, C. Y. ,Yu, S. L. ,Pan, S. L.,Teng, C. H. ,Lin, J. C. ,Yang, P. C. ,Lee, K. H. ,'Antitumor Agents 288: Design, Synthesis, SAR, and Biological Studies of Novel Heteroatom-Incorporated Antofine and Cryptopleurine Analogues as Potent and Selective Antitumor Agents',J. Med. Chem.,vol54.5097-5107,2011-07
2011.03 Nakagawa-Goto, K.,Wu, P. C.,Bastow, K. F.,Yang, S. C.,Yu, S. L.,Chen, H. Y.,Lin, J. C.,Goto, M.,Yang, P. C.,Lee, K. H.,'Antitumor agents 283. Further elaboration of Desmosdumotin C analogs as potent antitumor agents: Activation of spindle assembly checkpoint as possible mode of action',Bioorg Med Chem,vol19(5).1816-1822,2011.03
2009-07 Yang, Xiaoming ,Shi, Qian ,Liu, Yi-Nan ,Zhao, Guiyu ,Bastow, Kenneth F. ,Lin, Jau-Chen,Yang, Shuenn-Chen ,Yang, Pan-Chyr ,Lee, Kuo-Hsiung ,'Antitumor Agents 268. Design, Synthesis, and Mechanistic Studies of New 9-Substituted Phenanthrene-Based Tylophorine Analogues as Potent Cytotoxic Agents',J Med Chem,vol52.5262-5268,2009-07
2009-04 Lin, Jau-Chen,Yang, Shuenn-Chen ,Hong, Tse-Ming ,Yu, Sung-Liang ,Shi, Qian ,Wei, Linyi ,Chen, Hsuan-Yu ,Yang, Pan-Chyr , Lee, Kuo-Hsiung,'Phenanthrene-Based Tylophorine-1 (PBT-1) Inhibits Lung Cancer Cell Growth through the Akt and NF-KB Pathways',J. Med. Chem,vol52.1903-1911,2009-04
2008-06 Wu, Cheng-Chung , Lin, Jau-Chen,Yang, Shuenn-Chen ,Lin, Chiu-Wen ,Chen, Jeremy J.W. ,Shih, Jin-Yuan ,Hong, Tse-Ming ,Yang, Pan-Chyr ,'Modulation of the expression of the invasion-suppressor CRMP-1 by COX-2 inhibition via reciprocal regulation of Sp1 and C/EBP alpha',Mol Cancer Ther,vol7.1365-1375,2008-06
2006-07 YU, DAH-SHYONG ,LIN, JAU-CHEN ,HSIEH, DAR-SHIH ,LEE, CHI-FENG ,CHANG, SUN-YRAN ,'Modulation of MDR-1 gene by MIF and GSTpi with drug resistance generation in hormone independent prostate cancer',Arch Androl (Systems Biology in Reproductive Medicine ),vol52.283-291,2006-07
2006-05 Lee, Shiao-Pieng ,Chang, Chien-Ping ,Lee, Shou-Lun ,Hsia, Yi-Jan ,Chuang, Tzu-Ling ,Lin, Jau-Chen ,Liang, San-Chi ,Nieh, Shih ,Yin, Shih-Jiun ,'Immunochemical features in the classification of human alcohol dehydrogenase family',Alcohol,vol39.13-20,2006-05
2005-11 LIN, JAU-CHEN ,CHANG, SUN-YRAN ,HSIEH, DAR-SHIH ,LEE, CHI-FENG ,YU, DAH-SHYONG ,'Modulation of MAPK cascades by Id-1: Acquired Drug Resistance of Hormone Independent Prostate Cancer Cells',THE JOURNAL OF UROLOGY,vol174.2022-2026,2005-11
2005-05 LIN, JAU-CHEN ,CHANG, SUN-YRAN ,HSIEH, DAR-SHIH ,LEE, CHI-FENG ,YU, DAH-SHYONG ,'The association of Id-1, MIF and GSTpi with acquired drug resistance in hormone independent prostate cancer cells',ONCOLOGY REPORTS,vol13.983-988,2005-05
研討會論文
期間 內容
2012.03.17 黃于芳,林昭成,李國雄,卓貴美,王懷詩,吳建春,'Effects of Antofine on Expression of the Gap Junction Protein Cx43 in Astrocytes',27屆生醫年會,臺灣,2012.03.17
2011.04.30 林昭成,吳靜宜,林子傑,洪澤民,楊泮池,'甲基化抑制腫瘤相關蛋白(TROP2)基因的表達會藉由IGF-1R的訊息傳導途徑促進肺腺癌細胞的生長',台彎癌症醫學聯合會,臺灣,台北,2011.04.30
2011.04.02 Ching-Wen Lin,Jau-Chen Lin,Yih-Leong Chang,Hsuan-Yu Chen,Szu-Hua Pan,Tse-Ming Hong,Pan-Chyr Yang,'The role of a novel oncomiR, miR-135b, in lung cancer metastasis and clinical application ',Annual Meeting 2011 of the American Association for Cancer Research,USA,Orlando,2011.04.02
2010.12.10 高葦婷,卓貴美,王敏如,楊順真,楊泮池,林昭成,'The Inhibitory Effect of Antofine on Lipopolysaccharide-Induced Acute Lung Injury',台灣基因體暨遺傳學會2010年轉譯醫學研討會暨論文競賽,臺灣,2010.12.10
2009.04.18 Yi-Ying Wu,Szu-Hua Pan,Jau-Chen Lin,Konan Peck,Ruey-Bing Yang,Tse-Ming Hong,Pan-Chyr Yang,'MECHANISMS OF TUMOR PROGRESSION, INVASION, AND METASTASIS ',Annual Meeting 2009 of the American Association for Cancer Research,USA,Denver,2009.04.18
2008.04.12 Yang, Shuenn-Chen ,Lin, Jau-Chen,Yang, pan-chyr,'WLY-1 induce cell cycle G2M arrest and apoptosis through inhibiting NF-kB pathway in lung cancer cells',Annual Meeting 2008 of the American Association for Cancer Research,San Diego,2008.04.12
2007.04.14 Lin, Jau-Chen ,Hong, Tse-Ming ,Yang, Pan-Chyr ,'Epigenetic Regulation of CRMP1 Family Protein in Lung Cancer: A candidate tumor suppressor gene',Annual Meeting 2007 of the American Association for Cancer Research,Los Angeles,2007.04.14
2005.08.15 LIN, JAU-CHEN,Shaw, Yeng-Jeng ,CHEN, CHING-SHIH,'The identification of ECG-derived DNA hypomethylating agents',Midwest Taiwanese Symposium on Science and Technology,2005.08.15
2004.06.14 LIN, JAU-CHEN,CHANG, SUN-YRAN,YU, DAH-SHYONG ,'The role of Id-1 in drug resistance acquistion of prostate cancer',he annual meeting of Life Science Department of NDMC, Jun, 2004,臺灣,2004.06.14
2004.03.16 LIN, JAU-CHEN ,YU, DAH-SHYONG ,CHANG, SUN-YRAN ,'The signal transduction study of Id-1 and MIF-related multidrug resistance in prostate cancer',annual meeting of Taiwan Surgical Association, ROC, Mar, 2004,臺灣,2004.03.16
2003.08.30 LIN, JAU-CHEN,YU, DAH-SHYONG , CHANG, SUN-YRAN,'The Correlation of ID1, MIF and GSTpi with acquired drug resistance of rat prostate cancer (I/II)',annual meeting of Urological Association of Taiwan,臺灣,2003.08.30
2003.08.30 LIN, JAU-CHEN ,CHANG, SUN-YRAN ,YU, DAH-SHYONG ,'The profile study of transcription factors driven by over-expression of drug-resistant related gene Id-1 in rat prostate cancer cell (II/II)',annual meeting of Urological Association of Taiwan, ROC, Auguest, 2003,臺灣,2003.08.30
研究獎勵
年度 單位 獎項
107 輔仁大學 指標性期刊論文獎勵
107 Fu-Jen Catholic University 107年度教學績優教師
102 輔仁大學 指標性期刊論文獎勵
102 輔仁大學 指標性期刊論文獎勵
101 輔仁大學 指標性期刊論文獎勵
100 第十六屆台灣癌症聯合學術年會 第十六屆台灣癌症聯合學術年會壁報論文競賽基礎組(優等)
研究計畫
期間 主持人 計畫名稱 贊助單位 贊助金額 職稱
2023-08-01至2024-07-31 呼吸治療學系/林昭成/教授 血液游離DNA特定基因的突變頻率與LDCT篩檢結果的關聯性研究 null 400000.0000
2021-06-01至2022-07-31 「探討CCL5/RANTES在內毒素引發的急性肺損傷所扮演的角色」計畫 null 250000.0000
2020-08-01至2021-07-31 呼吸治療學系/林昭成/教授 探討FJU-C28的作用對肺部慢性發炎引起代謝改變導致體重流失與肌肉耗損的影響 國科會 1100000.0000
2018-08-01至2019-07-31 林昭成 「評估FJU-Cs 化合物抑制全身性發炎反應之治療效果」計畫 null 500000.0000
2017-08-01至2018-07-31 林昭成 探討YXM-43減弱內毒素引起急性肺損傷的分子作用機轉 null 300000.0000
2017-01-01至2017-12-31 林昭成 藉由抑制蛋白質去磷酸甲基酯?增強胃癌化療藥敏感性研究 null 314109.0000
2016-10-01至2017-09-30 呼吸治療學系/林昭成/教授 利用體外與小鼠體內模式探討FJU-Cs化合物抑制bleomycin引發肺部纖維化之研究 null 500000.0000
2016-10-01至2017-09-30 林昭成 利用體外與小鼠體內模式探討FJU-Cs化合物抑制bleomycin引發肺部纖維化之研究 null 500000.0000
2015-08-01至2016-07-31 林昭成 發展PBT衍生物治療內毒素引發敗血症休克之體外與小鼠體內模式研究 null 100000.0000
2014-08-01至2015-07-31 TROP2在肺癌癌化過程中的分子作用機轉 (3/3) 國科會 1140000.0000
2013-08-01至2014-07-31 林昭成 TROP2在肺癌癌化過程中的分子作用機轉 (2/3) 國科會 1140000.0000
2012-08-01至2013-07-31 林昭成 TROP2在肺癌癌化過程中的分子作用機轉 (1/3) 國科會 1140000.0000
2012-01-01至2012-12-31 林昭成,張炎德 探討tylophorine衍生物抑制內毒素引發肺損傷的作用機轉 204000.0000
2012.01.01至2012.12.31 林昭成,穆淑琪 探討PBT-1衍生物抑制活化肥胖細胞產生介白素-33 (Interleukin-33)之分子機轉 700000.0000
2011-08-01至2012-07-31 林昭成,徐志育 探討TROP2基因在EGFR-TKI敏感性肺癌細胞中所扮演的角色 400000.0000
2010.08.01至2011.07.31 林昭成 探討ㄧ種新穎腫瘤相關蛋白Trop2 在肺癌的角色及其臨床上的應用 國科會 800000.0000
2010.06.01至2011.05.31 林昭成,徐志育,龍芳 探討gefitinib 和PBT-1的合併治療在肺癌EGFR-TKI抗藥性細胞生長的協同抑制效果 國泰綜合醫院 500000.0000
校內服務
校內服務內容
期間 內容
2020-08-01至2021-07-31 校課程委員會委員(校課程委員會委員)
2017-08-01至2019-07-31 毒化物管理委員會委員(毒化物管理指導)
2013-08-01至2014-07-31 校課程委員會委員(校課程委員會委員)
2011.12.24至2011.12.24 指導員([肝癌肝炎篩檢活動]擔任學生義工指導員)
2011.10.15至2011.10.15 指導人(台灣歡呼兒協會舉辦[100年度會員大會]活動擔任節目表演指導人)
2011.08.01至2012.07.31 委員(輔仁大學醫學院院務會議委員)
2011.08.01至2012.07.31 委員(輔仁大學醫學院學術研究發展委員會委員)
2011.08.01至2012.07.31 導師(呼吸治療學系導師)
2010.08.01至2011.07.31 委員(呼吸治療學系系務會議學生事務委員會)
2010.08.01至2011.07.31 委員(呼吸治療學系系務會議招生委員會)
2010.08.01至2011.07.31 委員(呼吸治療學系系務會議課程委員會)
2010.08.01至2011.07.31 委員(輔仁大學醫學院院務會議委員)
2010.08.01至2011.07.31 委員(輔仁大學醫學院學術研究發展委員會委員)
校外服務
校外服務內容
期間 內容
2009.10.01至2011.06.30 病理科顧問(協助馬偕病理科腫瘤分子診斷技術的建立)
擔任委員
擔任委員內容
期間 內容
2017-08-01至2018-07-31 醫學教育中心委員(醫學教育中心委員)
2017-08-01至2018-07-31 委員(輔仁大學環安衛中心毒性化學物質管理委員)
2016-09-01至2017-07-31 碩士學位考試委員(碩士學位考試委員)
2016-08-01至2021-07-31 院教師評審委員(院教師評審委員)
2016-08-01至2019-07-31 醫學院院務委員(醫學院院務委員)
2016-08-01至2019-07-31 系評審委員(系評審委員)
2016-08-01至2018-07-31 醫學院國際交流委員會委員(醫學院國際交流委員會委員)
2016-08-01至2018-07-31 醫學院毒化物委員(環安衛毒化物委員)
2016-08-01至2017-07-31 編輯委員(期刊編輯委員)
2015-08-01至2016-07-31 校務會議院代表(校務會議院代表)
2015-08-01至2016-07-31 院學術發展委員會委員(院學術發展委員會委員)
2014-08-01至2016-07-31 院課程委員會委員(院課程委員會委員)
2014-08-01至2015-07-31 校學生獎懲委員會委員(校學生獎懲委員會委員)
2013-08-01至2014-07-31 校總務會議院代表(校總務會議院代表)
2013-08-01至2014-07-31 院課程委員會委員(院課程委員會委員)