學歷
學校 系所 學位
美國約翰霍普金斯大學 人類遺傳暨分子生物學 博士
國立臺灣大學 醫事技術學系 學士
經歷
期間 單位 部門 職稱
行政院衛生署 檢疫總所 薦任技士
美國耶魯大學 醫學院 博士後研究員
美國約翰霍普金斯大學 甘迺迪醫學研究中心 博士後研究
美國約翰霍普金斯大學 生物學系 助教
專長
人類分子遺傳
基因剔除小鼠
生物化學-脂質代謝
學術著作
期刊論文
期間 內容
Since 2015
1: Chao WC, Lu JF, Wang JS, Chiang TH, Lin LJ, Lee YL, Chou PT. Unveiling the structural features of nonnative trimers of human superoxide dismutase 1. Biochim Biophys Acta Gen Subj. 2020 Mar;1864(3):129483. doi: 10.1016/j.bbagen.2019.129483. Epub 2019 Nov 14. PubMed PMID: 31734464.
2: Huang KC, Wang ML, Chen SJ, Kuo JC, Wang WJ, Nhi Nguyen PN, Wahlin KJ, Lu JF, Tran AA, Shi M, Chien Y, Yarmishyn AA, Tsai PH, Yang TC, Jane WN, Chang CC, Peng CH, Schlaeger TM, Chiou SH. Morphological and Molecular Defects in Human Three-Dimensional Retinal Organoid Model of X-Linked Juvenile Retinoschisis. Stem Cell Reports. 2019 Nov 12;13(5):906-923. doi: 10.1016/j.stemcr.2019.09.010. Epub 2019 Oct 24. PubMed PMID: 31668851; PubMed Central PMCID: PMC6895767.
3: Liang JS, Huang H, Wang JS, Lu JF. Phenotypic manifestations between male and female children with CDKL5 mutations. Brain Dev. 2019 Oct;41(9):783-789. doi: 10.1016/j.braindev.2019.05.003. Epub 2019 May 20. PubMed PMID: 31122804.
4: Liang, JS, Wang, JS, Lin, LJ, Yang, MT, Hung, KL, Lu, JF. Genetic Diagnosis in Children with Epilepsy and Developmental Delay/Mental Retardation Using Targeted Gene Panel Analysis. Neuropsychiatry (London) 2018 Dec 29; 8(5):1577-85
5: Chao WC, Chiang TH, Chaudhari PD, Lin LJ, Lu JF, Hong BC, Wang JS, Lin TC, Shen JY, Chou PT. The azatryptophan-based fluorescent platform for in vitro rapid screening of inhibitors disrupting IKKβ-NEMO interaction. Bioorg Chem. 2018 Dec;81:504-511. doi: 10.1016/j.bioorg.2018.09.006. Epub 2018 Sep 11. PubMed PMID: 30245232.
6: Peng CH, Huang KC, Lu HE, Syu SH, Yarmishyn AA, Lu JF, Buddhakosai W, Lin TC, Hsu CC, Hwang DK, Shen CN, Chen SJ, Chiou SH. Generation of induced pluripotent stem cells from a patient with X-linked juvenile retinoschisis. Stem Cell Res. 2018 May;29:152-156. doi: 10.1016/j.scr.2018.04.005. Epub 2018 Apr 11. Erratum in: Stem Cell Res. 2019 Jan;34:101388. PubMed PMID: 29674172.
7: Su DJ, Lu JF, Lin LJ, Liang JS, Hung KL. SCN2A mutation in an infant presenting with migrating focal seizures and infantile spasm responsive to a ketogenic diet. Brain Dev. 2018 Sep;40(8):724-727. doi: 10.1016/j.braindev.2018.03.005. Epub 2018 Apr 4. PubMed PMID: 29625812.
8: Liang JS, Lin LJ, Lin HC, Yang MT, Wang JS, Lu JF. An unusual GFAP mutation in a Taiwanese child with infantile Alexander disease. Pediatr Neonatol. 2018 Dec;59(6):624-627. doi: 10.1016/j.pedneo.2017.12.009. Epub 2017 Dec 26. PubMed PMID: 29339051.
9: Yang HC, Yang CH, Huang MY, Lu JF, Wang JS, Yeh YQ, Jeng US. Homology Modeling and Molecular Dynamics Simulation Combined with X-ray Solution Scattering Defining Protein Structures of Thromboxane and Prostacyclin Synthases. J Phys Chem B. 2017 Dec 21;121(50):11229-11240. doi: 10.1021/acs.jpcb.7b08299. Epub 2017 Dec 8. PubMed PMID: 29168638.
10: Chao WC, Lin LJ, Lu JF, Wang JS, Lin TC, Chen YH, Chen YT, Yang HC, Chou PT. Unveiling the water-associated conformational mobility in the active site of ascorbate peroxidase. Biochim Biophys Acta Gen Subj. 2018 Mar;1862(3):451-459. doi: 10.1016/j.bbagen.2017.10.022. Epub 2017 Dec 22. PubMed PMID: 29104043.
11: Liang JS, Lin LJ, Yang MT, Wang JS, Lu JF. The therapeutic implication of a novel SCN2A mutation associated early-onset epileptic encephalopathy with Rett-like features. Brain Dev. 2017 Nov;39(10):877-881. doi: 10.1016/j.braindev.2017.06.003. Epub 2017 Jul 11. PubMed PMID: 28709814.
12: Hung KL, Liang JS, Wang JS, Chen HJ, Lin LJ, Lu JF. Association of a novel GABRG2 splicing variation and a PTGS2/COX-2 single nucleotide polymorphism with Taiwanese febrile seizures. Epilepsy Res. 2017 Jan;129:1-7. doi: 10.1016/j.eplepsyres.2016.11.004. Epub 2016 Nov 14. PubMed PMID: 27871023.
13: Chen YT, Chao WC, Kuo HT, Shen JY, Chen IH, Yang HC, Wang JS, Lu JF, Cheng RP, Chou PT. Probing the polarity and water environment at the protein-peptide binding interface using tryptophan analogues. Biochem Biophys Rep. 2016 Jun 2;7:113-118. doi: 10.1016/j.bbrep.2016.05.022. eCollection 2016 Sep. PubMed PMID: 28955897; PubMed Central PMCID: PMC5613298.
14: Chao WC, Shen JY, Yang CH, Lan YK, Yuan JH, Lin LJ, Yang HC, Lu JF, Wang JS, Wee K, Chen YH, Chou PT. The In Situ Tryptophan Analogue Probes the Conformational Dynamics in Asparaginase Isozymes. Biophys J. 2016 Apr 26;110(8):1732-1743. doi: 10.1016/j.bpj.2016.03.029. PubMed PMID: 27119634; PubMed Central PMCID: PMC4850355.
15: Liu JS, Chiang TH, Wang JS, Lin LJ, Chao WC, Inbaraj BS, Lu JF, Chen BH. Induction of p53-independent growth inhibition in lung carcinoma cell A549 by gypenosides. J Cell Mol Med. 2015 Jul;19(7):1697-709. doi: 10.1111/jcmm.12546. Epub 2015 Mar 17. PubMed PMID: 25781909; PubMed Central PMCID: PMC4511366.
研究計畫
期間 主持人 計畫名稱 贊助單位 贊助金額 職稱
磷脂甘油脂肪酸轉移酶之表現與功能分析
磷脂甘油脂肪酸轉移酶在第二型肺泡細胞之功能研究
子宫球蛋白同源基因產物在支氣管上皮細胞之功能研究
以酵母菌為模式研究神經退化性疾病X-linked Adrenoleukodystrophy (X-ALD)之生化缺陷機轉
神經退化性疾病X-linked Adrenoleukodystrophy (X-ALD)致病分子機轉之研究
第二型沛泡細胞特有胞器--層質體之蛋白質體分析
肺泡第二型細胞特有基因FR-105之研究
第二型肺泡細胞特有基因之研究
第二型肺泡細胞分化機轉的研究
其他教學經驗
其他教學經驗
期間 內容
化學系/生物化學
全人教育/當代生物醫學課題
基礎醫學研究所碩士班/進階生物化學
臨床心理學系/遺傳學
醫學系/生物化學、傳學導論