學歷
學校 系所 學位
國立臺灣大學 醫學院解剖學暨細胞生物學研究所 博士
經歷
期間 單位 部門 職稱
2023.08 輔仁大學 學術特聘教授
2021.09 - 2022.02 輔仁大學 研發處研究管理中心 主任
2016.08 - 2021.07 輔仁大學 生物醫學暨藥學研究所 教授兼任所長
2015.08 - 2016.07 輔仁大學 基礎醫學研究所 教授兼任所長
2015.08 - 輔仁大學 醫學系 教授
2015.02 - 2015.07 輔仁大學 醫學教育中心 主任
2011.02 - 2015.07 輔仁大學 醫學系 副教授
2005.08 - 2011.01 輔仁大學 醫學系 助理教授
2004.02 - 2005.07 國立臺灣大學 醫學院醫學系解剖學暨細胞生物學科 助教
專長
周邊神經損傷研究
疼痛生物學
解剖學
神經解剖學
學術著作
期刊論文
期間 內容
1. Chun-Ta Huang、Li-Kai Wang、June-Horng Lue、Seu-Hwa Chen、Yi-Ju Tsai* (2024) Lactobacillus Plantarum intake mitigates neuropathic pain behavior via enhancing macrophage M2 polarization in a rat model of peripheral neuropathy. Biomedicine & pharmacotherapy 175:116769.
2. Chun-Ta Huang、Po-Heng Chen、Seu-Hwa Chen、June-Horng Lue、Yi-Ju Tsai* (2023) Curcumin promotes microglial M2 polarization and suppresses chronic constriction injury-induced neuropathic pain in a rat model of peripheral neuropathy. Nutrition 109:112004.
3. Giou-Teng Yiang、Chia-Chao Wu、Chien-Lin Lu、Wan-Chung Hu、Yi-Ju Tsai、Yiao-Mien Huang、Wen-Lin Su、Kuo-Cheng Lu (2023) Endoplasmic reticulum stress in elderly patients with COVID-19: Potential of melatonin treatment. Viruses 5(1):156.
4. Kuan-Ming Chiu、Yen-Ling Hung、Su-Jane Wang、Yi-Ju Tsai、Nan-Lin Wu、Cher-Wei Liang、Der-Chen Chang、Chi-Feng Hung (2021) Anti-allergic and anti-inflammatory effects of Neferine on RBL-2H3 Cells. International Journal of Molecular Sciences 22(20):10994.
5. Chun-Ta Huang、Seu-Hwa Chen、Chi-Fen Chang、Shih-Chang Lin、June-Horng Lue、Yi-Ju Tsai* (2020) Melatonin reduces neuropathic pain behavior and glial activation through MT2 melatonin receptor modulation in a rat model of lysophosphatidylcholine-induced demyelination neuropathy. Neurochemistry International 140:104827.
6. Chun-Ta Huang、June-Horng Lue、Tong-Hong Cheng、Yi-Ju Tsai* (2020) Glycemic control with insulin attenuates sepsis-associated encephalopathy by inhibiting glial activation via the suppression of the nuclear factor kappa B and mitogen-activated protein kinase signaling pathways in septic rats. Brain Research 1738:146822.
7. Chun-Ta Huang、Yi-Ju Tsai、Chao-Chi Ho*、Chong-Jen Yu (2019) Radial endobronchial ultrasound-guided transbronchial biopsy for peripheral pulmonary malignancy: biopsy- or brushing-first? BMC Pulmonary Medicine 19(1):193.
8. Te-Wei Ho、Chun-Ta Huang*、Yi-Ju Tsai、Angela Shin-Yu Lien、Feipei Lai、Chong-Jen Yu (2019) Metformin use mitigates the adverse prognostic effect of diabetes mellitus in chronic obstructive pulmonary disease. Respiratory Research 20(1):69.
9. Chun-Ta Huang, Seu-Hwa Chen, Shih-Chang Lin, Wei-Ting Chen, June-Hog Lue, Yi-Ju Tsai*. (2018) Erythropoietin reduces nerve demyelination, neuropathic pain behavior and microglial MAPKs activation through erythropoietin receptors on schwann cells in a rat model of peripheral neuropathy. GLIA 66(11):2299-2315.
10. Chun-Ta Huang, Seu-Hwa Chen, June-Hog Lue, Chi-Fen Chang, Wen-Hsin Wen, Yi-Ju Tsai*. (2016) Neurosteroid allopregnanolone suppresses median nerve injury-induced mechanical hypersensitivity and glial extracellular signal-regulated kinase activation through γ-aminobutyric acid type A receptor modulation in the rat cuneate nucleus. Anesthesiology 125:1202-1218.
11. Melissa C. Lipford, Kannan Ramar, Yao-Jen Liang, Chii-Wann Lin, Yun-Ting Chao, Jen An, Chih-Hsien Chiu, Yi-Ju Tsai, Chih-Hung Shu, Fei-Peng Lee, Rayleigh Ping-Ying Chiang*. (2016) Serotnin as a possible biomarker in obstructive sleep apnea. Sleep Medicine Reviews 28:125-132.
12. Chun-Ta Huang, Yi-Ju Tsai*. (2016) Docosahexaenoic acid confers analgesic effects after median nerve injury via inhibition of c-Jun N-terminal kinase activation in microglia. Joual of Nutritional Biochemistry 29:97-106.
13. Chun-Ta Huang, Yi-Ju Tsai, Pi-Ru Tsai, Chong-Jen Yu, Wen-Je Ko*. (2015) Epidemiology and outcome of severe sepsis and septic shock in surgical intensive care units in Northe Taiwan. Medicine 94(47):e2136.
14. Te-Wei Ho, Yi-Ju Tsai, Sheng-Yuan Ruan, Chun-Ta Huang*, Feipei Lai, Chong-Jen Yu. The HINT Study Group (2014) In-hospital and one-year mortality and their predictors in patients hospitalized for first-ever chronic obstructive pulmonary disease exacerbations: a nationwide population-based study. PLoS One 9(12), e114866.
15. Jiann-Hog Yeh, Chun-Ta Huang*, Chia-Hsiung Liu, Sheng-Yuan Ruan, Yi-Ju Tsai, Ying-Chun Chien, Ching-Yao Yang, Chun-Kai Huang, Chia-Lin Hsu, Lu-Cheng Kuo, Pei-Lin Lee, Shih-Chi Ku, Ping-Hung Kuo, Chong-Jen Yu. The HINT Study Group (2014) Cautious application of pleural N-terminal pro-B-type natriuretic peptide in diagnosis of congestive heart failure pleural effusions among critically ill patients. PLoS One 9(12), e115301.
16. Chun-Ta Huang, Rayleigh Ping-Ying Chiang, Chih-Li Chen, Yi-Ju Tsai*. (2014) Sleep deprivation aggravates median nerve injury-induced neuropathic pain and enhances microglial activation by suppressing melatonin secretion. Sleep 37(9), 1513-1523.
17. Chun-Ta Huang*, Hsien-Ho Lin, Sheng-Yuan Ruan, Meng-Sui Lee, Yi-Ju Tsai, Chong-Jen Yu. (2014) Efficacy and adverse events of high frequency oscillatory ventilation in adult patients with acute respiratory distress syndrome: a meta-analysis. Critical Care 18(3), R102.
18. Chun-Ta Huang, Li-Na Lee, Chao-Chi Ho, Chin-Chung Shu, Sheng-Yuan Ruan, Yi-Ju Tsai, Jann-Yuan Wang*, Chong-Jen Yu. (2014) High serum levels of procalcitonin and soluble TREM-1 correlated with poor prognosis in pulmonary tuberculosis. Joual of Infection 68(5), 440-447.
19. Chun-Ta Huang*, Yi-Ju Tsai, Jou-Wei Lin, Sheng-Yuan Ruan, Huey-Dong Wu, Chong-Jen Yu .(2014) Application of heart-rate variability in patients undergoing weaning from mechanical ventilation. Critical Care 18(1), R21.
20. Shih-Ping Hung, Ming-Jen Sheu, Ming-Chieh Ma, Jui-Ting Hu, Ya-Yun Sun, Chin-Cheng Lee, Yuan-Chiang Chung, Yi-Ju Tsai, Jing-Yuan Wang, Chih-Li Chen*. (2014) Runx1-deficient afferents impair visceral nociception, exacerbating dextran sodium sulfate-induced colitis. Brain Behavior and Immunity 35, 96-106.
21. Chun-Ta Huang, Yi-Ju Tsai, Pi-Ru Tsai, Wen-Je Ko*. (2013) Extracorporeal membrane oxygenation resuscitation in adult patients with refractory septic shock. Joual of Thoracic and Cardiovascular Surgery 146(5), 1041-1046.
22. Shih-Chang Lin, Yi-Ju Tsai, Chun-Ta Huang*, Yao-Wen Kuo, Sheng-Yuan Ruan, Yu-Chung Chuang, Chong-Jen Yu. (2013) Prognostic value of plasma N-terminal pro B-type natriuretic peptide levels in pneumonia patients requiring intensive care unit admission. Respirology 18(6), 933-941.
23. Hsin-Ying Wang, Yi-Ju Tsai, Seu-Hwa Chen, Chi-Te Lin, June-Hog Lue*. (2013) Lysophosphatidylcholine causes neuropathic pain via the increase of neuronal nitric oxide synthase in the dorsal root ganglion and cuneate nucleus. Pharmacology Biochemistry and Behavior 106, 47-56.
24. Yi-Ju Tsai, Kannan Ramar, Yao-Jen Liang, Po-Han Chiu, Nelson Powell, Chao-Yun Chi, Tzu-Chen Lung, Wesley Wen-Yang Lin, Po-Jung Tseng, Ming-Ying Wu, Kuan-Chiao Chien, Edward M. Weaver, Fei-Peng Lee, Chia-Mo Lin, Kuang-Chao Chen, Rayleigh Ping-Ying Chiang*. (2013) Peripheral neuropathology of the upper airway in obstructive sleep apnea syndrome. Sleep Medicine Reviews 17(2), 161-168.
25. Rayleigh Ping-Ying Chiang, Chun-Ta Huang, Yi-Ju Tsai*. (2013) Melatonin reduces median nerve injury-induced mechanical hypersensitivity via inhibition of microglial p38 mitogen-activated protein kinase activation in rat cuneate nucleus. Joual of Pineal Research 54(2), 232-244.
26. Chun-Ta Huang, Sheng-Yuan Ruan, Wei-Yu Liao, Yao-Wen Kuo, Chi-Ying Lin, Yi-Ju Tsai, Chao-Chi Ho*, Chong-Jen Yu. (2012) Risk factors of pneumothorax after endobronchial ultrasound-guided tansbronchial biopsy for peripheral lung lesions. PLoS One 7(11), e49125.
27. Chun-Ta Huang, Yi-Ju Tsai, Wei-Yu Liao, Pei-Chen Wu, Chao-Chi Ho*, Chong-Jen Yu, Pan-Chyr Yang. (2012) Endobronchial ultrasound-guided transbronchial biopsy of peripheral pulmonary lesions: how many specimens are necessary? Respiration 84(2), 128-134.
28. Seu-Hwa Chen, Yi-Ju Tsai, Chi-Te Lin, Hsin-Ying Wang, Shin-Fang Li, June-Hog Lue*. (2012) Changes in GABA and GABAB receptor expressions are involved in neuropathy in the rat cuneate nucleus following median nerve transection. Synapse 66(6), 561-572.
29. Chun-Ta Huang, Yi-Ju Tsai, Huey-Dong Wu, Jann-Yuan Wang*, Chong-Jen Yu, Li-Na Lee, Pan-Chyr Yang. (2012) Impact of non-tuberculous mycobacteria on pulmonary function decline in chronic obstructive pulmonary disease. Inteational Joual of Tuberculosis and Lung Disease 16(4), 539-545.
30. Yi-Ju Tsai*, Chun-Ta Huang, Shih-Chang Lin, Jiann-Hog Yeh. (2012) Effects of regional and whole-body hypothermic treatment before and after median nerve injury on neuropathic pain and glial activation in rat cuneate nucleus. Anesthesiology 116(2), 415-431.
31. Seu-Hwa Chen, Yi-Ju Tsai, Hsin-Ying Wang, Chi-Te Lin, Shin-Fang Li, June-Hog Lue*. (2012) Decreases of glycine receptor expression induced by median nerve injury in the rat cuneate nucleus contribute to NPY release and c-Fos expression. Life Sciences 90(7-8), 278-288.
32. Hsin-Ying Wang, Yi-Ju Tsai, Seu-Hwa Chen, Chi-Te Lin, June-Hog Lue*. (2012) Nitric oxide implicates c-Fos expression in the cuneate nucleus following electrical stimulation of the transected median nerve. Neurochemical Research 37(1), 84-95.
33. Chi-Te Lin, Yi-Ju Tsai, Hsin-Ying Wang, Seu-Hwa Chen, Tzu-Yu Lin, June-Hog Lue*. (2012) Pre-emptive treatment of lidocaine attenuates neuropathic pain and reduces pain-related biochemical markers in the rat cuneate nucleus in median nerve chronic constriction injury model. Anesthesiology Research and Practice 2012, 1-9.
34. Shih-Chang Lin, Jiann-Hog Yeh, Chih-Li Chen, Shiu-Huey Chou, Yi-Ju Tsai*. (2011) Effects of local lidocaine treatment before and after median nerve injury on mechanical hypersensitivity and microglia activation in rat cuneate nucleus. European Joual of Pain 15(4), 359-367.
35. Yuan-Chiang Chung, Yi-Ju Tsai, Ting-Ying Shiu, Ya-Yun Sun, Pin-Fang Wang, Chih-Li Chen*. (2011) Screening large numbers of expression pattes of transcription factors in late stages of the mouse thymus. Gene Expression Pattes 11(1-2), 84-92.
36. Chun-Ta Huang, Yi-Ju Tsai, Jun-Yu Fan, Shih-Chi Ku*, Chong-Jen Yu. (2010) Cryptococcosis and tuberculosis co-infection at a university hospital in Taiwan, 1993-2006. Infection 38(5), 373-379.
37. Chi-Te Lin, Yi-Ju Tsai, Seu-Hwa Chen, Hsin-Ying Wang, Lung-Huang Lin, June-Hog Lue*. (2010) Early expression of injury-induced neuropeptide Y in primary sensory neurons and the cuneate nucleus in diabetic rats with median nerve transection. Joual of Chemical Neuroanatomy 40(2), 102-111.
38. Ming-Tzer Lin, Yi-Ju Tsai, Chun-Ta Huang*. (2010) Right-sided cardiophrenic mass in an older woman. American Family Physician 82(8), 971-972.
39. Chun-Ta Huang, Rouh-Fang Yen, Mei-Fang Cheng, Ya-Chieh Hsu, Pin-Fei Wei, Yi-Ju Tsai, Meng-Feng Tsai, Jin-Yuan Shih*, Chih-Hsin Yang, Pan-Chyr Yang. (2010) Correlation of F-18 fluorodeoxyglucose-positron emission tomography maximal standardized uptake value and EGFR mutations in advanced lung adenocarcinoma. Medical Oncology 27(1), 9-15.
40. Jiann-Jy Chen, June-Hog Lue, Lung-Huang Lin, Chun-Ta Huang, Rayleigh Ping-Ying Chiang, Chih-Li Chen, Yi-Ju Tsai*. (2010) Effects of pre-emptive drug treatment on astrocyte activation in the cuneate nucleus following rat median nerve injury. Pain 148(1), 158-166.
研討會論文
期間 內容
Shih-Hsin Chang Chien、Tzu-Meng Yang、Dorji Harnod、Tun-Hui Chung、Yi-Ju Tsai,"Gross anatomy dissection-assisted ultrasound learning: Focusing on heart and liver",The 34th Joint Annual Conference of Biomedical Science,Taipei,Taiwan,2019
Ko-Yen Huang、Yi-Ju Tsai,"Electroacupuncture confers analgesic effects in a rat model of neuropathic pain by inhibiting expression of inflammatory cytokines",The 32th Joint Annual Conference of Biomedical Science,Taipei,Taiwan,2017
Rayleigh Ping-Ying Chiang、Yi-Ju Tsai,"Abnormal afferent nerve endings in the uvulae of patients with obstructive sleep apnea",The 24th Annual Meeting of the Associated Professional Sleep Societies, LLC,San Antonio,Texas,U.S.A.,2010
Chun-Ta Huang、Yi-Ju Tsai,"Amelioration of peripheral neuropathy by implantation of neural stem cells in an animal model",The 2nd Pan Pacific Symposium on Stem Cells Research,Taichung,Taiwan,2009 (Best Poster Award)
研究計畫
期間 主持人 計畫名稱 贊助單位 贊助金額 職稱
國科會計畫: 探討不同星形膠細胞表現型之外泌體於神經性疼痛發生與治療的角色-從形態、功能到分子層面的深入分析 (113.08-114.07)
科技部計畫: 以慢性壓迫性損傷的疼痛模型,探討周邊神經病變與腸道微生物菌叢、代謝物以及黏膜屏障功能間的交互影響 (三年期計畫) (110.08-113.07)
科技部計畫: 探討感覺神經節內細胞凋亡在重症多發性神經病變中扮演之角色以及抗細胞凋亡物質的神經保護成效 (指導大專學生研究計畫) (110.07-111.02)
科技部計畫: 以大鼠神經病變疼痛模型探討活化性以及抑制性受體在調控微小膠細胞表現型的角色 (三年期計畫) (107.08-110.07)
科技部計畫: 多元不飽和脂肪酸omega-3在重症神經病變中的保護機轉 (指導大專學生研究計畫) (108.07-109.02)
科技部計畫: 以大鼠敗血症模型探討重症神經病變之神經組織變化與相關機轉 (三年期計畫) (103.08-106.07)
國科會計畫: 以創傷性腦損傷的研究實例配合發展小型動物正子斷層攝影的定量追蹤技術 (三年期計畫,共同主持人) (102.08-105.07)
國科會計畫: 在大白鼠神經病變模式中Docosahexaenoic acid對於神經保護作用之研究 (101.08-102.07)
國科會計畫: 探討睡眠剝奪於大白鼠軀體與內臟疼痛造成之影響 (三年期計畫) (98.08-101.07)
國科會計畫: 正中神經損傷配合局部或全身低體溫處理神經膠細胞以及發炎前驅物對大白鼠楔狀神經核及其背根神經節表現變化的影響 (96.08-98.07)
國科會計畫: 正中神經損傷配合藥劑處理對大白鼠楔狀神經核神經膠細胞表現變化的影響(95.05-96.04)
其他合作案包括與新光醫院及國泰醫院之合作計畫案多件
其他教學經驗
其他教學經驗
期間 內容
醫學系/大體解剖學實驗、資源學習(含胚胎學)、神經解剖學、PBL(基礎醫學單元、內分泌單元)
護理學系/解剖學、解剖學實驗
學士後護理學系/解剖學
公共衛生學系/解剖學、解剖學實驗
呼吸治療學系/解剖學、解剖學實驗
職能治療學系/系統解剖學(含實驗)、實地解剖學(含實驗)
營養學系/解剖學、組織學
生物醫學暨藥學研究所/老化特論、神經科學概論暨神經疾病動物模式
食品營養博士學位學程/當代研究、研究模式方法特論
生技醫藥博士學位學程/現代醫學與疾病模式研究特論
長期照護與健康管理進修學士學位學程/解剖學
全人教育中心/腦科學探索