學歷
學校 系所 學位
清華大學 生命科學所 博士
經歷
期間 單位 部門 職稱
臺北醫學大學 醫學系生化學科 副教授
私立長庚大學 博士後研究員
中研院 生物醫學研究所 助理研究員
專長
生物化學
學術著作
期刊論文
期間 內容
1.K-G Shyu, S-T Huang, H-S Kuo, W-P Cheng, Yuh-Ling Lin* 2007 The anti- tumor activity of a novel bis-aziridinylnaphthoquinone (AZ4) mediated the cell cycle arrests and apoptosis in the Non-Small Cell Lung Cancer Cell Line NCI-H460. Acta Pharmacologica Sinica 28: 559-566 (SCI)
2.Y.-C. Peng, H.-S. Kuo, H.-D. Tsai, Y.-P. Yang, Y.-L. Lin* 2006 The lethal effect of bis-type aziridinylnaphthoquinone derivative on oral cancer cancer cells (OEC-M1) associated with anti-apoptotic protein bcl-2. Bioorganic Medicinal Chemistry 14: 263-272 (SCI)
3.S.-T. Huang, Yuh-Ling Lin 2006 New latent fluorophore for DT-diaphorase Organic Letter 8: 265-268 (SCI)
4.Y.-P. Yang, H.-S. Kuo, H.-D. Tsai, Y.-C. Peng, Y.-L. Lin* 2005 The p53-dependent apoptotic pathway of breast cancer cells (BC-M1) induced by bis-type bioreductive compound aziridinylnaphthoquine. Breast Cancer Research 7: R19-R27. (SCI)
5.S.-T. Huang, H.-D. Tsai, H.-S. Kuo, Y.-P. Yang, Y.-C. Peng, Y.-L. Lin* 2004 A novel bis-aziridinylnaphtho-quinone with anti-solid tumor activity in which induced apoptosis is associated with altered expression of bcl-2 protein. ChemBiochem 5: 797-803. (SCI)
6.Sheng-Tung Huang, Yuh-Ling Lin* 2004 Total synthesis of the complex I inhibitor: Evaluation of the biological activity of pterulone and its derivatives. Fu-Jen Journal Medicine 2: 311-317.
7.Sheng-Tung Huang, Hsien-Shou Kuo, Chun-Mao Lin, Hsin-Da Tsai, Yi-Chen Peng, Chien-Tsu chen, and Yuh-Ling Lin* 2003 Synthesis And Biological Evaluation of Novel Bis-Aziridinylnaphthoquinone Thiol- Ethers. Oncology Research /Anti-Cancer Drug Design 13:199-204. (SCI)
8.Yuh-Ling Lin, Hsien-Shou Kuo, Yi-Wen Wang, Sheng-Tung Huang 2003 Efficient entry to 1-benzoxepine ring skeleton via tandem SN2/Wittig reaction. Total synthesis of NADH: ubiquinone oxidoreductase (complex I) antagonist pterulinic acid. Tetrahedron 59: 1277-1281. (SCI)
9.Sheng-Tung Huang, Hsien-Shou Kuo, Chiao-Long Hsiao, Yuh-Ling Lin* 2002 Efficient syhthesis of “redox-switched” naphthoquinone thiol-crown ethers and their biological activity evaluation. Bioorganic & Medicinal Chemistry 10: 1947-1952 (SCI)
10.Tze-Che Wang, Chu-Chi Hsiu, Yi-Ping Chin, Yuh-Ling Lin* 2002 Autoantibody expression against different source of oxidized low density lipoprotein in patients with acute myocardial infarction. Thrombosis Research 2076: 1-5 (SCI)
11.Yuh-Ling Lin* Chien-Tsu Chen, Su-Cheng Lin, Cheng Lee, Hsien-Shou Kuo, Chun-Mean Shih, Yuan-Hsun Hsu, Yi-Ping Chin and Err-Cheng Chan 2000 A simple method to determine urea concentration using intact Helicobacter pylori and Brom Creasol Purple as a pH indicator. Biotechnology Letter 22: 1077-1079 (SCI)
12.Yuh-Ling Lin*, Hsien-Shou Kuo, Chien-Tsu Chen, Sheng-Chu Kuo 2000 A biological energy from the igneous rock enhances cell growth and enzyme activity. Nuclear Medicine and Biology 27: 1611-1616 (SCI)
13.Tze-Che Wang, Yuh-Ling Lin 2000 The expression of antibodies against oxidized low density lipoprotein in patients with acute myocardial infarction. New Taipei Journal of Medicine 2: 239-244
14.Err-Cheng Chan, Chien-Tsu Chen, Yuh-Ling Lin, Kuei-Tian Chen 1999 Signal pathway and pepsinogen secretion in Helicobacter pylori-infected human gastric adenocarcinoma. Bioorganic & Medicinal Chemistry Letter 3: 421-425 (SCI)
15.Yuh-Ling Lin, Jai-Shin Liu, Chien-Tsu Chen, Kuei-Tian Chen, Err-Cheng Chan 1998 Identification of neutral and acidic sphingomyelinase in Helicobacter pylori. FEBS Letter 423: 249-253.(SCI)
16.Err-Cheng Chan, C. Allen Chang, Tzong-Zeng Wu, Yuh-Ling Lin 1998 Effects of recombinant lysostaphin on cytotoxicity and interleukine-8 level in normal human epidermal keratinocytes cell line. Biotechnology Letter 20: 1053-1056 (SCI)
研究計畫
期間 主持人 計畫名稱 贊助單位 贊助金額 職稱
1.新雙體臨床藥物(BTZQ)其衍生物的化學合成、抗癌機轉研究及動物模式活性評估(國科會)
2.新合成西奈西昆化合物AZ-1對抗乳癌細胞作用機制的探討(國科會)
3.高血脂及冠狀動脈疾病患者中體內抗氧化的低密度脂蛋抗體的表現及相關性(新光醫院合作計畫)
4.奈米化中草藥對大屬模式酒精性肝炎影響之研究(國泰醫院合作計畫)
其他教學經驗
其他教學經驗
期間 內容
護理系/生物化學
醫學系/生物化學及實驗
醫學系/PBL小班tutor
基礎醫學研究所/進階生物化學
基礎醫學研究所/細胞生物技術學
基礎醫學研究所/基礎分子生物學
全人教育/現代醫學及生物技術的開發
化學系/生物化學
公衛系/普通生物學